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Common clinical practice in many tropical paediatric departments is that chloramphenicol courses are limited to 2 weeks due to concerns about anaemia. However, this approach is not supported by current research and animal models. We used chloramphenicol for 6 weeks in 146 children with septic arthritis. All the children improved clinically. Most children were anaemic on presentation (mean haemoglobin [Hb] 8.43 SD 1.9), but the anaemia improved rapidly with clinical resolution of the infection and was maintained at 6 months after presentation (mean Hb 10.57 SD 1.86).

Original publication




Journal article


Trop Doct

Publication Date





114 - 115


Anemia, Arthritis, Infectious, Child, Child, Preschool, Chloramphenicol, Follow-Up Studies, Hemoglobins, Humans, Infant, Malawi, Protein Synthesis Inhibitors, Salmonella Infections, Time Factors